Effect of phospholipase A2 inhibitors during infection caused by Leishmania (Leishmania) a

An experimental dataset from a study investigating the leishmanicidal effect of three Phospholipase A2 inhibitors (MAFP, BEL, AA) on Leishmania amazonensis. The data likely contains results from in vitro assays with promastigote and amastigote parasite forms and in vivo infection models using BALB/c mice, measuring effects like lesion size and parasitism. The study was authored by Maria L. A. C. Bordon and sourced from the Papers with Code platform.

Use Cases

• Evaluating drug efficacy based on in vitro parasite viability assays mentioned in the description
• Analyzing host toxicity based on hepatotoxicity results from mouse models described in the study
• Comparing inhibitor selectivity based on the described in vitro and in vivo parasitism outcomes
• Modeling parasite virulence mechanisms related to Phospholipase A2 activity as discussed in the conclusions

Strengths

• Data is derived from controlled in vitro and in vivo experiments described in the abstract
• Study investigates three specific inhibitors (MAFP, BEL, AA) with clear experimental outcomes
• Includes results from both parasite forms (promastigote and amastigote) and a mouse model

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Last update date is unknown; freshness unverified

Provenance

Source

Papers with Code, authored by Maria L. A. C. Bordon

Collection Method

Likely experimental data from laboratory assays and animal infection models