Effects of 5-Ion Beam Irradiation and Hindlimb Unloading on Metabolic Pathways in Plasma a

NASA research on male WAG/Rij rats subjected to simulated spaceflight stressors. The dataset includes behavioral test results from Open Field, Novel Object Recognition, and Forced Swim Test assays, linked to metabolic pathway analysis in plasma, hippocampus, and cortex tissues collected 6-9 months post-exposure. Data was last updated on March 13, 2026.

Use Cases

• Modeling associations between depressive-like behaviors and plasma metabolite levels based on the described behavioral assays.
• Analyzing the interaction between hindlimb unloading and radiation on spatial habituation learning performance.
• Identifying metabolic pathway alterations in brain tissues linked to specific environmental stressors described in the study.

Strengths

• Data originates from a controlled NASA experiment with specific radiation doses (1.5 Gy) and a simulated 5-ion beam.
• Links behavioral outcomes from three distinct tests to long-term metabolic changes measured 6 months later.
• Examines multiple tissue types: plasma, hippocampus, and cortex.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to a single rodent strain (WAG/Rij) and male subjects only.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Experimental data from animal behavior assays and tissue metabolite analysis.

Time Range

Data collection period not explicitly specified; results published or updated by 2026.

Freshness

Last updated 2026-03-13 20:12:08.257707; freshness should be verified.

Geography

Laboratory study; geographic location not specified.