Effects of fecal microbiota transplantation and probiotics on the gut microbiome in antibi

A pilot randomized controlled trial from a single center evaluated gut microbiome restoration in 40 critically ill, antibiotic-treated sepsis patients. The dataset includes 16S rDNA sequencing results for gut microbiota composition and clinical inflammatory markers assessed at baseline, one week, and two weeks post-treatment. It was authored by Yuanzhuo Chen and registered on ClinicalTrials.gov (NCT05578196).

Use Cases

• Comparing microbial alpha-diversity changes between intervention groups based on Chao1, Shannon, and Simpson indices mentioned in the description
• Analyzing shifts in specific bacterial taxa like Bacteroides and Enterobacteriaceae abundance following FMT or probiotic treatment
• Assessing the reduction in pathogenic potential of gut microbiota using BugBase analysis results described
• Evaluating donor-recipient microbiome similarity through enterotype analysis referenced in the study

Strengths

• Data from a controlled clinical trial with 40 patients randomized into three groups (Control n=20, Probiotics n=10, FMT n=10)
• Includes longitudinal measurements at three time points (baseline, one week, two weeks) for microbiome and inflammatory markers
• Study protocol is registered on ClinicalTrials.gov (NCT05578196), providing a public reference

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data is from a single-center pilot study with 40 patients, which may limit generalizability

Provenance

Source

figshare

Collection Method

Data collected as part of a single-center, prospective, exploratory pilot randomized controlled trial.

Freshness

Last updated 2026-05-23 04:40:04; freshness should be verified