Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57B
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Description
Experimental data from a study assessing cardiac function and structure in male C57BL/6J mice exposed to low-dose oxygen ions, protons, and gamma rays. The dataset includes results from western blot, histology, and immunohistochemistry assays measuring ejection fraction, fractional shortening, apoptosis, tissue remodeling, and immune cell infiltration markers at intervals up to 9 months post-irradiation. The data was produced by the National Aeronautics and Space Administration and last updated in March 2026.
Use Cases
Modeling dose-response relationships for cardiac function based on ejection fraction and fractional shortening measurements.
Analyzing time-series trends in tissue remodeling based on levels of α smooth muscle cell actin and collagen type III.
Classifying immune response severity based on protein abundance of CD2, CD68, and CD45 markers.
Comparing the relative biological effectiveness of different radiation types (oxygen ions, protons, gamma rays) on cardiac endpoints.
Strengths
Includes multiple radiation types (oxygen ions, protons, gamma rays) and combination exposures for comparative analysis.
Provides longitudinal measurements at 2 weeks, 3, 5, 7, and 9 months post-irradiation.