Effects of Oral Isotretinoin on Nasal Complaints in 54 Acne Patients

Hamdi Taşlı conducted a study assessing nasal side effects in patients with severe acne undergoing oral isotretinoin therapy. The research involved 54 subjects evaluated with subjective questionnaires (NOSE and VAS) and objective tests (rhinomanometry and saccharine) at admission and during treatment. Results indicate that nasal complaints like dryness, crusting, and epistaxis increased significantly over the three-month therapy period.

Use Cases

• Analyzing the progression of nasal dryness and crusting based on VAS questionnaire scores over time
• Modeling the relationship between isotretinoin therapy duration and objective nasal resistance measurements from rhinomanometry
• Studying patient-reported nasal obstruction complaints using NOSE questionnaire data
• Investigating the correlation between subjective epistaxis scores and objective saccharine test results

Strengths

• Includes data from 54 subjects, providing a basis for statistical analysis
• Combines subjective patient-reported outcomes (NOSE, VAS) with objective clinical measurements (rhinomanometry, saccharine)
• Contains longitudinal measurements taken at three time points: admission, first month, and third month of treatment

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Last update date is unknown; freshness unverified

Provenance

Source

Hamdi Taşlı via paperswithcode

Collection Method

Clinical study involving patient assessments with questionnaires and medical tests.