Mouse Brain Inflammasome Response to 37-Day Spaceflight on ISS

NASA's Rodent Research 1 Mission data measures inflammasome activation and cytokine levels in mouse brain tissue after 37 days on the International Space Station. The dataset derives from Electrochemiluminescence Immunoassay (ECLIA) analysis of dissected brains from the SpaceX-4 mission launched on September 21, 2014. Results indicate decreased inflammasome signaling in spaceflight mice compared to ground controls.

Use Cases

• Modeling the impact of spaceflight on innate immune signaling in the brain based on inflammasome protein levels.
• Comparing cytokine expression profiles between spaceflight and ground control groups based on TNF-alpha, IL-6, and other cytokine assays.
• Investigating the biological effects of long-duration microgravity exposure on rodent models based on data from a 37-day ISS mission.

Strengths

• Data originates from a controlled NASA mission with specific launch (September 21, 2014) and duration (37 days) parameters.
• Analysis includes specific cytokine targets: TNF-alpha, IL-2, IFN-gamma, IL-5, IL-6, IL 12p70, and IL-10.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Electrochemiluminescence Immunoassay (ECLIA) and immunoblotting of brain tissue from mice flown on the ISS.

Time Range

Mission dates: September 21, 2014, to October 25, 2014.

Freshness

Last updated 2026-03-13 20:10:46.255278; freshness should be verified.

Geography

International Space Station and ground control locations.