Mouse Brain Inflammasome Response After 37 Days on the International Space Station

NASA's Rodent Research 1 Mission analyzed inflammasome activation in mouse brains after a 37-day stay on the International Space Station in 2014. The dataset contains results from Electrochemiluminescence Immunoassay (ECLIA) tests measuring inflammatory cytokine levels. It compares flight, ground control, and baseline groups to assess the effects of spaceflight on innate immune signaling.

Use Cases

• Modeling the effect of spaceflight on neuroimmune signaling based on inflammasome protein levels.
• Comparing cytokine expression (TNF-alpha, IL-6, etc.) between spaceflight and terrestrial control groups.
• Investigating long-duration microgravity's impact on brain tissue using ECLIA assay data.

Strengths

• Data originates from a controlled NASA mission (Rodent Research 1) with defined launch and return dates (September 21 to October 25, 2014).
• Includes comparisons across three experimental groups: flight, ground control, and baseline.
• Assay method (Electrochemiluminescence Immunoassay) is explicitly stated.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count and dataset scale are unknown, which may limit suitability assessment.
• File format is listed as BIN, which may require specific tools for access and interpretation.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Immunoblotting and Electrochemiluminescence Immunoassay (ECLIA) of dissected mouse brain tissue from the ISS mission.

Time Range

September 21, 2014 to October 25, 2014

Freshness

Last updated 2026-03-13 20:11:27.490983; freshness should be verified.

Geography

International Space Station and ground control locations.