Spaceflight Bone Effects in Ovariectomized Rats from STS-62

12-week-old Fisher 344 rats were ovariectomized and randomized into baseline (n=6), ground control (n=12), or spaceflight (n=12) groups for a 14-day mission. The National Aeronautics and Space Administration (NASA) conducted this study, with results derived from micro–computed tomography (mCT) assays. This dataset contains results only for the ovariectomized animals, investigating bone- and compartment-specific effects of spaceflight.

Use Cases

• Modeling bone loss due to hormonal insufficiency based on ovariectomy data
• Analyzing compartment-specific effects of microgravity based on comparisons of weight-bearing and non-weight-bearing bones
• Studying cancellous versus cortical bone response based on volume fraction and trabecular structure metrics
• Comparing spaceflight-induced bone changes to ground control conditions based on group randomization

Strengths

• Study includes a baseline group (n=6), ground control (n=12), and spaceflight group (n=12) for comparison.
• Focuses on a specific biological model (ovariectomized rats) for controlled hormone insufficiency.
• Data derives from a specific assay method: micro–computed tomography (mCT).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is limited to ovariectomized animals; results for ovary-intact reference groups are not included in this dataset.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Experimental study using micro–computed tomography (mCT) assay on rats from the STS-62 spaceflight mission.

Time Range

Study involved a 14-day spaceflight.

Freshness

Last updated 2026-03-13 19:55:48.050209; freshness should be verified.

Geography

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