Mouse Skeletal Muscle Gene Expression After 11-Day Spaceflight and Ground-Based Analogs

A microarray expression analysis of gastrocnemius muscle from mice flown on the STS-108 shuttle mission for 11 days and 19 hours, compared to Earth-based controls. The dataset also includes results from ground-based hindlimb suspension (12 days) and reloading (3.5 hours) experiments to simulate unloading and post-landing effects. The data was produced by the National Aeronautics and Space Administration.

Use Cases

• Identify gene expression signatures of muscle atrophy based on spaceflight versus Earth control comparisons
• Study the effects of mechanical unloading on muscle tissue based on the hindlimb suspension experiment data
• Analyze rapid transcriptional changes during muscle reloading based on the 3.5-hour reloading simulation
• Compare spaceflight-induced adaptations to ground-based analog models mentioned in the description

Strengths

• Includes a direct spaceflight experiment from the STS-108 mission with a defined duration of 11 days and 19 hours
• Contains controlled ground-based analog experiments (12-day hindlimb suspension and 3.5-hour reloading)
• Produced by the authoritative organization National Aeronautics and Space Administration

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data is stored in a BIN file format, which may require specific tools for access and analysis

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Microarray expression analysis performed on mouse gastrocnemius muscle tissue.

Time Range

Associated with the STS-108 shuttle flight and contemporaneous ground experiments.

Freshness

Last updated 2026-03-13 20:14:08.301114; freshness should be verified

Geography

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