Metabolic Effects of HIV Drugs in Prediabetic Rats, 42 Subjects

42 male Sprague-Dawley rats were divided into non-prediabetic and diet-induced prediabetic groups, then treated with two antiretroviral regimens for 12 weeks. The dataset contains body weight, oral glucose tolerance test responses, plasma lipids, and ELISA-quantified markers like HbA1c, insulin, glucagon, and C-peptide. It was authored by Amogelang Sedibe and last updated on 2026-04 15.

Use Cases

• Modeling drug-induced insulin resistance based on HOMA-IR and HOMA-β indices
• Comparing metabolic outcomes of different antiretroviral regimens based on treatment group data
• Analyzing the progression of diet-induced prediabetes based on oral glucose tolerance test responses
• Investigating the relationship between hepatic glucose output and insulin sensitivity based on assay results

Strengths

• Data from a controlled animal study with 42 subjects across 6 distinct treatment and metabolic condition groups
• Includes multiple time-point measurements at 4-week intervals over a 12-week treatment period
• Contains calculated indices (HOMA-IR, HOMA-β) derived from primary biochemical parameters

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data is from a specific rat model and may not directly translate to human physiology

Provenance

Source

figshare

Collection Method

Experimental data from a controlled laboratory study on rats.

Time Range

Covers a 12-week treatment period following a 20-week diet induction phase.

Freshness

Last updated 2026-04-15 09:24:39

Geography

Laboratory study; geographic location is not specified.