Single-Molecule SERS Spectra of pH-Dependent Amylin Species in Aqueous Solutions

3600 SERS measurements from twenty parallel sessions characterize methylene blue and nile blue A mixtures for single-molecule analysis. The dataset includes real-time SERS spectra of tyrosine under pH changes from 1.0 to 13.0 and spectra of 10 μM human islet amyloid polypeptide (hIAPP) solutions incubated at pH 5.5 and 7.4. It was contributed by Wenhao Fu via paperswithcode and includes supplementary PDB files of simulated hIAPP conformations.

Use Cases

• Analyze single-molecule binding events based on the 3600 SERS measurements of dye mixtures mentioned in the description.
• Model pH-dependent conformational changes of human islet amyloid polypeptide (hIAPP) based on SERS spectra collected at pH 5.5 and 7.4.
• Validate molecular dynamics simulations based on the provided PDB files of monomeric hIAPP conformations with different charge states.
• Develop algorithms for real-time spectral analysis based on the time-series SERS data of tyrosine under changing pH conditions.

Strengths

• Includes 3600 SERS measurements from twenty parallel experimental sessions, suggesting a substantial experimental basis.
• Provides data under controlled pH conditions (1.0, 5.5, 7.4, 13.0), enabling analysis of pH-dependent effects.
• Contains supplementary structural data in the form of PDB files for simulated hIAPP conformations.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale modeling.
• Last update date is unknown; freshness unverified.

Provenance

Source

paperswithcode

Collection Method

Data appears to be collected from optical plasmonic tweezer-coupled SERS platform experiments.