Ultrasound-assisted synthesis of 5-aryl-tetrahydropyrimido[4,5-b]quinolindione derivatives via a multicomponent reaction and subsequent formylation with Vilsmeier-Haack reagent were performed. Compounds were prepared by a one-pot method from specific pyrimidinone precursors, dimedone, and aromatic aldehydes through a Mannich-type reaction sequence. The dataset, associated with an open-access paper by Jorge Trilleras, describes a procedure featuring experimental simplicity and good yields without metallic catalysts.
Use Cases
- Predicting reaction yields for ultrasound-assisted organic synthesis based on described reaction conditions.
- Modeling the properties of pyrimido[4,5-b]quinoline-4,6-dione derivatives based on the synthesis procedure.
- Analyzing the efficiency of multicomponent reactions for specific chemical scaffolds mentioned in the description.
- Studying the effect of Vilsmeier-Haack formylation conditions on the described β-chlorovinylaldehyde products.
Strengths
- Procedure is described as having experimental simplicity and good yields.
- Method avoids the use of metallic catalysts, which is noted as a feature.
- Associated with an open-access (green) license, facilitating reuse.
Limitations
- Row count is unknown, which may limit suitability assessment.
- Column-level documentation is absent; field semantics must be inferred after download.
- Last update date is unknown; freshness unverified.
Provenance
- Source
- paperswithcode, associated with a research paper.
- Collection Method
- Data likely originates from laboratory experiments on chemical synthesis.