In-Vivo Whole Cell Patch-Clamp Data for Mouse Neocortical Interneuron Profiling

Parviz Ghaderi provides electrophysiological recordings from three transgenic mouse lines (VGAT-ChR2-YFP, SST-ChR2-YFP, PV-ChR2-YFP) under urethane anesthesia. The dataset includes raw and processed membrane potential data sampled at 20 kHz from parvalbumin-positive (PV), somatostatin-positive (SST) interneurons, and nearby pyramidal neurons in the primary visual cortex. Data originates from experiments approved by the RIKEN Brain Science Institute Animal Experiment Committee and is associated with a 2017 Scientific Reports publication.

Use Cases

• Classifying neural cell subtypes based on recorded membrane potential time-series data.
• Analyzing electrophysiological response patterns of PV, SST, and pyramidal neurons to optogenetic stimulation.
• Developing and benchmarking algorithms for automated cell type identification, as suggested by the included demo and complete code.
• Studying pairwise interactions between different interneuron types and pyramidal cells based on recorded distances between cell pairs.

Strengths

• Data includes simultaneous dual whole-cell recordings from specific interneuron and pyramidal cell pairs, enabling paired analysis.
• Recordings were sampled at a high frequency of 20 kHz, providing detailed temporal resolution.
• Includes processed data in SPSS format and raw data in MATLAB format, along with demo and complete code for cell type identification.

Limitations

• Row count and dataset scale are unknown, which may limit suitability assessment for large-scale modeling.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.

Provenance

Source

RIKEN Brain Science Institute (Animal Experiment Committee approved procedures).

Collection Method

In-vivo whole-cell patch-clamp recordings from urethane-anesthetized transgenic mice under a two-photon microscope.