Quercetin Effects on Broiler Thymus Necroptosis via Nrf2/PERK Signaling

A 34.4 MB research document authored by Yu Xia and last updated in April 2026 details a study on quercetin's protective role in poultry immune tissues. The work combines network pharmacology, bioinformatics, and experimental validation using broilers and MSB-1 cells. Findings elucidate how quercetin attenuates LPS-induced injury by regulating Nrf2/PERK signaling, calcium homeostasis, and inflammation.

Use Cases

• Study the molecular mechanisms of quercetin's antioxidant and anti-inflammatory effects based on the described Nrf2/PERK signaling pathway.
• Validate network pharmacology predictions for drug-gene interactions using the described experimental model of LPS-induced injury.
• Investigate necroptosis and endoplasmic reticulum stress in broiler thymus immune function based on the described experimental treatments with inhibitors and activators.

Strengths

• The dataset is a 34.4 MB document providing detailed methodological descriptions of combined network pharmacology, bioinformatics, and wet-lab experiments.
• Research includes experimental validation using specific chemical modulators (ML385, MK-28, NSA) mentioned in the description to explore detailed mechanisms.
• The work is licensed under CC-BY-4.0, permitting broad reuse and distribution.

Limitations

• The primary data format is a DOCX file; underlying raw experimental or bioinformatics data are not explicitly described or provided.
• Column-level documentation for any potential supplementary data is absent; field semantics must be inferred after download.
• Row count and dataset structure are unknown, which may limit suitability assessment for computational analysis.

Provenance

Source

figshare, author Yu Xia

Collection Method

Experimental study on broilers and MSB-1 cells combined with network pharmacology and bioinformatics analysis.

Freshness

Last updated 2026-04-28 07:00:07; freshness should be verified.