Emerald Bay: Single-Cell Transcriptomic Profiles of 1.8M Cells Under Drug Perturbation

Over 1.8 million single-cell transcriptomic profiles capture cellular responses to 91 anticancer drugs and combinations across 52 cell lines. Generated by Tahoe Therapeutics using their MOSAIC high-throughput platform, the dataset includes drug-phenotype readouts and transcriptional profiles at single-cell resolution. The dataset page was last updated on June 5, 2026.

Use Cases

• Predicting drug response mechanisms based on single-cell transcriptional profiles.
• Analyzing cell line heterogeneity in response to anticancer agents.
• Modeling the effects of drug combinations on tumor cell populations.
• Benchmarking single-cell analysis pipelines for high-throughput perturbation data.

Strengths

• Over 1.8 million individual cell profiles provide high statistical power.
• Covers 91 distinct drug treatments, including combinations, across 52 cell lines.
• Data is generated using a specialized high-throughput platform (MOSAIC) optimized for five-day culture.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count and file size are unknown, which may limit suitability assessment.
• Data may reflect biases inherent to the specific MOSAIC tumor pool and platform methodology.

Provenance

Source

Tahoe Therapeutics

Collection Method

Generated using the MOSAIC high-throughput platform.

Freshness

Last updated 2026-06-05 21:12:47; freshness should be verified.