Azole Resistance in Aspergillus fumigatus Clinical Isolates, 1994-2007

1,912 clinical Aspergillus fumigatus isolates collected from 1,219 patients at a University Medical Centre between 1994 and 2007. The dataset, from a study by Eveline Snelders of Radboud University Medical Center, investigates the prevalence and spread of itraconazole resistance, identifying a dominant genetic resistance mechanism. It includes phenotypic and molecular characterization of isolates from the Netherlands and other countries.

Use Cases

• Modeling the temporal emergence of antifungal resistance based on prevalence data from 1994-2007.
• Analyzing the correlation between specific genetic mutations (e.g., TR/L98H substitution) and elevated minimum inhibitory concentrations for multiple azoles.
• Investigating the geographic spread of resistant Aspergillus fumigatus strains based on isolates from multiple medical centers and countries.

Strengths

• 1,912 clinical isolates from 1,219 patients provide a substantial sample for analysis.
• Data spans a 14-year period (1994-2007), enabling longitudinal study of resistance emergence.
• Includes phenotypic data (minimum inhibitory concentrations) and molecular characterization (cyp51A gene mutations).
• Investigates isolates from 28 other medical centres in the Netherlands and 6 other countries for spread analysis.

Limitations

• Row count and column-level documentation for the underlying data are unknown.
• The license is closed, restricting reuse and redistribution.
• Data may reflect geographic and temporal bias inherent to the specific medical centers and time period studied.

Provenance

Source

Eveline Snelders, Radboud University Medical Center

Collection Method

Clinical isolates were collected from patient cultures and characterized using phenotypic and molecular methods; electronic patient files were used for clinical context.

Time Range

1994 to 2007

Geography

Primarily the Netherlands, with additional isolates from six other countries