SARS-CoV-2 Surface Glycoprotein Mutations Across 796 Isolates

A 2019 analysis of mutation frequency in the surface glycoprotein of 796 sequenced SARS-CoV-2 isolates from the GISAID and GenBank databases. The study by Saeed M. Hashimi of Griffith University identified 64 different protein-level mutations and found that 68.5% of isolates contain a D614 residue.

Use Cases

• Tracking viral evolution based on mutation frequency across geographic locations.
• Identifying potential antigenic drift based on cumulative mutations in the receptor binding domain.
• Analyzing the prevalence of specific residue variants, such as D614 versus G614.

Strengths

• Analysis includes 796 sequenced viral isolates.
• Identifies 64 distinct protein-level mutations.
• Quantifies the prevalence of the D614 residue (68.5%) versus G614 (31.5%).

Limitations

• Row count and column-level documentation are absent, requiring manual inspection after download.
• Data may reflect geographic and temporal bias inherent to the source databases and the early pandemic period.

Provenance

Source

GISAID and GenBank databases.

Collection Method

Multiple sequence alignment analysis of sequenced SARS-CoV-2 isolates.

Time Range

2019

Geography

Global, with isolates from multiple geographic locations.