Peng Ma authored a research document describing how Encephalomyocarditis virus evades interferon antiviral response. The document, uploaded to figshare on 2026-05-25, details the mechanism where the viral infection upregulates the E3 ubiquitin ligase RNF149, which targets JAK1 for ubiquitination and degradation. This finding provides a new strategy for treating viral infections.
Use Cases
- Analyze the role of RNF149 in inhibiting interferon antiviral response based on the described overexpression experiments
- Study the mechanism of JAK1 degradation via K27- and K33-linked ubiquitination based on the described protein interaction
- Model viral replication enhancement under suppressed JAK-STAT signaling based on the described knockout and overexpression results
Strengths
- Document is licensed under CC-BY-4.0, allowing for open reuse and distribution
- The description provides a specific molecular mechanism involving RNF149 and JAK1 ubiquitination
Limitations
- The dataset is a single 122.0 KB DOCX file, indicating a limited scope
- Row count and column-level documentation are absent; field semantics must be inferred after download
- Description metadata is limited; actual data quality requires manual inspection after download
Provenance
- Source
- figshare
- Freshness
- Last updated 2026-05-25 13:40:03; freshness should be verified