Mouse Liver Disease and Urinary Oxalate Synthesis Data

Sonia Fargue's dataset contains measurements from a study investigating endogenous oxalate synthesis in mouse models of metabolic dysfunction-associated steatotic liver disease (MASLD). The data includes 24-hour urinary oxalate and glycolate levels, activity of key liver enzymes (AGT, DGDH/GRHPR, GO, LDH, HOGA), and liver/kidney oxalate and glyoxylate content. The study used C57BL/6J and C57BL/6N mice fed high-fat or Western diets to induce mild and moderate MASLD stages, with a hydroxyproline challenge to probe glyoxylate metabolism.

Use Cases

• Analyzing the correlation between liver enzyme activity and urinary oxalate excretion in MASLD models.
• Comparing the metabolic response to a hydroxyproline challenge between different diet-induced MASLD severities.
• Investigating the relationship between liver pathology scores (NAFLD Fibrosis score) and measured metabolite levels.

Strengths

• Data is openly licensed under CC-BY-4.0, facilitating reuse and sharing.
• Study design includes two distinct mouse strains and diets to model different severities of MASLD.
• Includes a controlled metabolic challenge (hydroxyproline administration) to probe pathway dynamics.

Limitations

• Column names and a precise row count are not provided, limiting immediate understanding of the data structure.
• The dataset size (38502) is given but its unit (e.g., bytes, cells) and relation to rows/columns is unclear.
• Data is from a controlled animal model study, which may limit direct translation to human physiology.

Provenance

Source

Sonia Fargue

Collection Method

Experimental data from a controlled animal study measuring urinary metabolites, liver/kidney content, and enzyme activities.

Freshness

Last updated on 2026-03-20.