Engineered Bispecific Antibodies Against Multiple Ebolavirus Species

Research data from a 2026 figshare study by Jinge Zhou on engineered bispecific antibodies for ebolavirus protection. The dataset includes files analyzing three bsAb formats—CrossMab®, DVD-IgG, and IgG-ScFv—and their neutralizing activity and in vivo efficacy in mouse models. It provides a framework for rational antibody design against diverse ebolaviruses.

Use Cases

• Compare the neutralization potency of different bispecific antibody formats based on the described CrossMab®, DVD-IgG, and IgG-ScFv constructs.
• Model antibody design strategies for broad viral protection based on the framework for rational bsAb design mentioned in the description.
• Analyze in vivo efficacy data from mouse challenge models referenced in the study.
• Investigate cross-species efficacy against ebolaviruses like EBOV, SUDV, and BDBV based on the described research goal.

Strengths

• Dataset is 141.7 MB in size, indicating substantial content.
• Includes analysis of three distinct bispecific antibody formats (CrossMab®, DVD-IgG, IgG-ScFv).
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect experimental bias inherent to the specific mouse models and assays used.

Provenance

Source

figshare

Collection Method

Experimental research data from antibody engineering and virology challenge studies.

Time Range

Study published in 2026.

Freshness

Last updated 2026-05-04 14:40:11; freshness should be verified.

Geography

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