Engineered Modular Polyketide Synthases Data for Stereocontrol Analysis

Research data from figshare by Jie Zhang, last updated April 22, 2026, investigating stereoselectivity in engineered modular polyketide synthases. The dataset, 6.3 MB in size, likely contains results from mutagenic probing and platform experiments using components from pikromycin and rapamycin synthases. It provides strategies for controlling alkyl substituent orientations in complex polyketides.

Use Cases

• Modeling enoylreductase (ER) domain interactions with acyl carrier proteins (ACPs) based on mutagenic probing data.
• Analyzing stereochemical outcomes of ER-inserted modules in tetraketide-heptaketide synthase platforms.
• Investigating the role of ketosynthase (KS) swaps on intermediate saturation based on in vivo platform experiments.
• Training predictive models for methyl group orientation based on interactions with upstream and downstream KS domains.

Strengths

• Data is associated with a specific 6.3 MB research archive.
• Research is grounded in experimental platforms constructed from pikromycin and rapamycin synthases components.
• Includes findings from both in vitro and in vivo experimental approaches.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale statistical analysis.
• The dataset is relatively small at 6.3 MB, potentially limiting the scope of contained data.

Provenance

Source

figshare

Collection Method

Experimental data from mutagenic probing and platform construction in polyketide synthase research.

Time Range

Publication date suggests data is current as of 2026.

Freshness

Last updated 2026-04 22 14:33:40; freshness should be verified.

Geography

Geographic scope is not specified in the provided metadata.