Engineered Modular Polyketide Synthases Data for Stereocontrol

Jie Zhang's dataset on figshare, last updated April 22, 2026, contains experimental data on engineered modular polyketide synthases. The 64.7 KB Excel file likely documents results from mutagenic probing and platform testing to elucidate how enoylreductase domains set stereocenters. This research provides strategies for controlling alkyl substituent orientations in complex polyketides.

Use Cases

• Analyzing enoylreductase stereoselectivity based on mutagenic probing data
• Modeling domain interactions between ER, ACP, and KS based on platform construction results
• Designing stereochemical libraries of polyketides based on strategies for controlling methyl group orientation

Strengths

• Data is associated with a detailed study published on figshare
• File is provided in a structured, machine-readable XLSX format
• Dataset is licensed for non-commercial research use under CC-BY-NC-4.0

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset's 64.7 KB size indicates a very limited scope of experimental results

Provenance

Source

figshare, authored by Jie Zhang

Collection Method

Likely contains experimental results from in vitro and in vivo platform testing of engineered synthases.

Time Range

Study date is not specified; dataset was updated in 2026.

Freshness

Last updated 2026-04-22 14:33:41; freshness should be verified

Geography

Spatial coverage is not specified.