Protoglobin Engineering Data for Stereoconvergent Synthesis of N-Alkylated α-Aminoketones

Zi-Yang Qin published this dataset on figshare in May 2026. It contains data related to engineered protoglobin-derived hemoproteins that catalyze stereoconvergent intermolecular amination. The enzymatic platform processes mixtures of silyl enol ethers to produce α-aminoketones with yields up to 79% and enantiomeric excess up to 95%.

Use Cases

• Training models to predict enzymatic activity based on reaction conditions mentioned in the description
• Analyzing the relationship between protein engineering steps and stereochemical outcomes described in the study
• Benchmarking biocatalytic methods for converting alkene mixtures into enantiopure compounds as detailed in the work

Strengths

• Dataset includes results for reactions achieving up to 79% yield and 95% enantiomeric excess
• Focus on a stereoconvergent and enantiodivergent enzymatic transformation described as elusive in synthetic chemistry
• Data supports the synthesis of pharmaceutical compounds featuring aminoketone functionalities

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

figshare

Collection Method

Likely contains experimental data from directed evolution and catalytic performance testing.

Time Range

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Freshness

Last updated 2026-05-01 12:07:12; freshness should be verified

Geography

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