Engineering mitochondrial lipoate metabolism through <i>lpl</i>A expression improves alpha

A 585.5 KB document describes a metabolic engineering study in Pichia pastoris yeast. Fernando David Montalvo-Sandoval authored this research, which was last updated on May 12, 2026. The study evaluated the expression of a bacterial lipoate–protein ligase to improve alpha-lipoic acid production.

Use Cases

• Benchmarking alpha-lipoic acid production yields based on bioreactor performance data.
• Analyzing the impact of heterologous enzyme expression on microbial biomass growth.
• Studying the relationship between dissolved oxygen control and specific productivity in yeast fermentations.
• Investigating strategies for coupling exogenous activation pathways with endogenous lipoylation.

Strengths

• The dataset is associated with a specific, peer-reviewed research methodology involving stirred-tank bioreactor cultivation.
• Results include quantified improvements, such as a 42% increase in ALA accumulation and a 1.5-fold higher biomass yield.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (585.5 KB), suggesting limited scope.

Provenance

Source

Fernando David Montalvo-Sandoval

Collection Method

Experimental data from metabolic engineering and bioreactor cultivation of Pichia pastoris yeast.

Freshness

Last updated 2026-05-12 19:58:45; freshness should be verified.