Enhancer RNA and TDP-43 Expression Dynamics in Neural Differentiation

Epigenomic and transcriptomic data from embryonic stem cells and neural progenitor cells investigates enhancer RNA-mediated regulation of the TDP-43 gene. The dataset includes analysis of intergenic and intragenic enhancers, eRNA expression dynamics, and associated histone modification states. Yeonju Jang published this research on figshare in March 2026.

Use Cases

• Analyze correlations between eRNA expression levels and TDP-43 transcription during the ESC to NPC transition.
• Model stage-specific enhancer usage based on histone modification state data.
• Identify potential regulatory eRNA subsets by comparing expression profiles in pluripotent versus differentiated cell states.

Strengths

• Integrates epigenomic and transcriptomic analyses for a multi-omics perspective.
• Focuses on a specific, critical regulatory protein (TDP-43) in a defined biological process.
• Data is openly available under a permissive CC-BY-4.0 license.

Limitations

• The dataset is small at 7.4 MB, limiting the scale of analysis possible.
• Sample size and specific row/column counts are not provided, making reproducibility assessment difficult.
• Data is derived from a specific in vitro cell differentiation model, which may not fully reflect in vivo complexity.

Provenance

Source

figshare, authored by Yeonju Jang.

Collection Method

Integrative epigenomic and transcriptomic analyses of embryonic stem cells and derived neural progenitor cells.

Freshness

Last updated March 2026.