Mouse Germ Cell Multiomics Data for BPA/BPS Transgenerational Exposure Study

Liang Zhao published this dataset on figshare in May 2026. It contains single-nucleus multiomics data from a study on the transgenerational effects of prenatal exposure to bisphenol A (BPA) and bisphenol S (BPS) in mice. The data likely includes paired snRNA-seq and snATAC-seq results from neonatal spermatogonia across three generations (F1-F3) following exposure to environmentally relevant doses.

Use Cases

• Identify differentially expressed genes in germ cells based on transcriptomic data mentioned in the description.
• Analyze changes in chromatin accessibility (Differentially Accessible Peaks) based on snATAC-seq results.
• Investigate persistent transcription factor motif activities (e.g., DMRT1) across generations.
• Correlate epigenetic and transcriptomic alterations with observed reductions in adult sperm counts.

Strengths

• Data is derived from a systematic transgenerational study spanning F1 to F3 mouse generations.
• Uses paired single-nucleus multiomics (snRNA-seq and snATAC-seq) on the same nucleus for integrated analysis.
• Exposure doses (0.5, 50, 1000 μg/kg/b.w./day) are described as environmentally relevant.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale modeling.
• Data is specific to a murine model (CD-1 mice), which may limit direct translation to human biology.

Provenance

Source

Liang Zhao via figshare.

Collection Method

Single-nucleus multiomics (paired snRNA-seq and snATAC-seq) on THY1+ germ cells from prenatally exposed CD-1 mice.

Time Range

Study covers F0 to F3 generations; specific collection dates are not provided.

Freshness

Last updated 2026-05-04 16:05:10; freshness should be verified.

Geography

Laboratory study; geographic location is not specified.