Enzymatic C-Acylation Data for Tetramate Antibiotic Diversification

Anfu Wei's dataset on figshare, last updated May 14, 2026, contains data related to enzymatic C-acylation for diversifying tetramate antibiotic scaffolds. The 153.8 MB dataset likely includes experimental results characterizing a family of bacterial acyltransferases from species like Streptococcus macacae and Bacillus pseudomycoides. This work establishes an enzymatic strategy for expanding the chemical space of bioactive tetramate metabolites.

Use Cases

• Identifying novel acyltransferase enzymes based on the described family from distinct bacterial species.
• Analyzing substrate tolerance for tetramate acceptors and phenyl acyl ester donors as mentioned in the description.
• Evaluating the antibacterial activity of acylated products against methicillin-resistant Staphylococcus aureus.
• Exploring enzymatic C-C bond formation strategies in microbial natural product chemistry.

Strengths

• Dataset size is 153.8 MB, indicating a medium-scale collection of data.
• Focuses on a specific enzymatic strategy (C-acylation) for diversifying a widely distributed bioactive scaffold (tetramate).
• Includes characterization data for acyltransferases from four distinct bacterial species named in the description.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely contains experimental data from the identification and characterization of bacterial acyltransferases.

Time Range

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Freshness

Last updated 2026-05-14 08:50:12; freshness should be verified.

Geography

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