Enzymatic C-Acylation Data for Tetramate Antibiotic Diversification

A dataset related to the enzymatic diversification of tetramate antibiotic scaffolds. The data likely contains results from the characterization of a family of bacterial acyltransferases from species including Streptococcus macacae, Lactococcus hircilactis, Priestia megaterium, and Bacillus pseudomycoides. The dataset was authored by Anfu Wei, uploaded to figshare, and last updated on May 14, 2026.

Use Cases

• Identifying novel acyltransferase enzymes based on the described family from distinct bacterial species.
• Analyzing substrate tolerance for tetramate acceptors and phenyl acyl ester donors as mentioned in the description.
• Evaluating the antibacterial activity of acylated products against methicillin-resistant Staphylococcus aureus.
• Expanding the chemical space of tetramate metabolites using the described enzymatic platform.

Strengths

• Dataset size is 131.2 MB, indicating a medium-scale data volume.
• Includes data on four specific bacterial acyltransferases (SmaATase, LhATase, PmATase, BpATase).
• Description details a specific enzymatic strategy for C–C bond formation in microbial natural product chemistry.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from the identification and characterization of enzymatic reactions.

Time Range

null

Freshness

Last updated 2026-05-14 08:49:58; freshness should be verified.

Geography

null