Enzyme-Triggered Peptide-Drug Conjugate Data for Tumor-Selective Delivery

A dataset from a 2026 figshare study by Jiaying Wei on enzyme-activatable peptide-drug conjugates. It details a γ-glutamyltransferase-responsive peptide platform for targeted cancer therapy. The data likely contains results on cytotoxicity, internalization efficiency, and in vivo tumor growth suppression.

Use Cases

• Evaluating tumor-selective cytotoxicity based on GGT-overexpression mentioned in the description
• Analyzing peptide-drug conjugate solubility and potency improvements described for CPT-P-EE
• Modeling enzyme-triggered conformational switching for targeted delivery platforms

Strengths

• Data supports specific findings, such as a 5-fold higher cytotoxic potency in HepG2 cells and over 50-fold reduced toxicity to normal cells.
• The dataset is associated with a peer-reviewed research study establishing a generalizable platform.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Experimental research data from a study on peptide-drug conjugates.

Freshness

Last updated 2026-05-16 14:06:56; freshness should be verified.