Multiomic Data on Sarcomere-Desmosome Variants in Spontaneous Preterm Labor

A multiomic study from Hainan Maternal and Child Health Hospital investigates genetic and epigenetic factors in spontaneous preterm birth. The research employed genomics, transcriptomics, methylomics, and proteomics on a cohort of 146 women with spontaneous preterm labor. It identified 13 SNVs and pathogenic variants in the TTN gene and differential expression of lncRNAs and mRNAs associated with sarcomeres and desmosomes.

Use Cases

• Identify genetic risk factors for preterm labor based on SNVs and pathogenic variants in the TTN gene
• Study epigenetic regulation of sarcomeric genes based on methylation patterns in CpG promoters
• Analyze the role of long non-coding RNAs in placental gene expression based on lncRNA TPM3 data
• Investigate protein-level changes associated with uterine muscle contraction based on differentially expressed proteins

Strengths

• Integrated multiomic approach covering genomics, transcriptomics, methylomics, and proteomics
• Study cohort of 146 women with spontaneous preterm labor provides a specific patient population

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count for specific data tables is unknown, which may limit suitability assessment
• Last update date is unknown; freshness unverified

Provenance

Source

Hainan Maternal and Child Health Hospital

Collection Method

An integrated omics approach of systems biology applied to a pregnant cohort with a biobank of pregnant tissues.