ESBL-Transcriptomic-Data: Kidney Cell and Tubule RNA-Seq Studies

A 54.4 MB web archive from the Epithelial Systems Biology Laboratory (ESBL) at NHLBI, NIH, provides access to eight transcriptomic studies. The Knepper Lab compiled these databases, which include RNA-seq data from mouse and rat kidney cells and microdissected tubules under various physiological and experimental conditions. The archive was last updated on May 18, 2026.

Use Cases

• Compare gene expression profiles between collecting duct principal and intercalated cells based on the mouse transcriptomes listed.
• Analyze transcriptomic changes in response to drug treatment like tolvaptan in mpkCCD cell cultures.
• Study the genomic response to vasopressin using combined RNA Polymerase II ChIP-seq and RNA-seq data from mpkCCD cells.
• Investigate polyuria mechanisms by examining RNA-seq data from rat collecting ducts and cortical thick ascending limbs under unilateral ureteral obstruction.
• Profile solute carrier (SLC) gene family expression along the mouse renal tubule for transporter biology studies.

Strengths

• Data originates from the authoritative Epithelial Systems Biology Laboratory at the NHLBI, NIH.
• The archive consolidates eight distinct, previously published transcriptomic studies into a single access point.
• Full documentation is included within the web architecture, according to the description.

Limitations

• The 54.4 MB size suggests the archive contains metadata and web files, not the full underlying sequencing data, which likely resides elsewhere.
• Row and column counts for the actual data tables are unknown, limiting scale assessment.
• Column-level documentation is absent from the provided metadata; field semantics must be inferred after download.

Provenance

Source

Epithelial Systems Biology Laboratory (DIR, NHLBI, NIH), Knepper Lab.

Collection Method

Archived from previously published omic studies; the .zip file contains web architecture for data access.

Freshness

Last updated 2026-05-18 12:26:41.