Essential Oil of Pterodon Polygalaeflorus: Antinociceptive and Toxic Effects in Mice

A study by A.N. Coelho-De-Souza evaluates the antinociceptive and acute toxic effects of essential oil extracted from Pterodon polygalaeflorus seeds. The oil sample, extracted with a 2.4% yield, showed antinociceptive activity at doses of 20–60 mg/kg in mice, with a calculated median lethal dose (LD50) of 3.38 g/kg. Results suggest the antinociceptive effect is likely due to anti-inflammatory activities.

Use Cases

• Modeling dose-response relationships for antinociceptive effects based on administered doses (10–100 mg/kg).
• Analyzing chemical composition and bioactivity correlations based on major constituents like beta-elemene and trans-caryophyllene.
• Evaluating therapeutic index and safety margins based on the LD50 value and effective dose ranges.
• Studying anti-inflammatory mechanisms in pain models based on inhibition of formalin-induced and thermally stimulated nociception.

Strengths

• Specific chemical composition is provided, including beta-elemene (48.19%), trans-caryophyllene (19.51%), and epi-bicyclosesquiphellandrene (12.24%).
• Quantitative pharmacological results are reported, including a yield of 2.4%, an LD50 of 3.38 g/kg, and effective doses ranging from 20–60 mg/kg.
• Experimental outcomes are detailed across multiple standardized tests (acetic acid writhing, formalin test, thermal stimulation).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.

Provenance

Source

A.N. Coelho-De-Souza via paperswithcode

Collection Method

Experimental data from animal studies, with essential oil extracted by steam distillation.