Estradiol-Induced Immune Suppression in BLV-Infected Cattle During Parturition

Satoru Konnai from Hokkaido University presents data on immune suppression in pregnant cattle infected with bovine leukemia virus. The research analyzes prostaglandin E2 kinetics and Th1 immune responses before delivery in BLV-infected cattle. Findings suggest estradiol-induced PGE2 suppresses Th1 responses, which could contribute to disease progression.

Use Cases

• Modeling the relationship between estradiol levels and immune suppression based on described PGE2 kinetics.
• Analyzing Th1 response inhibition during parturition based on IFN-γ response data mentioned in the description.
• Investigating PGE2/EP4 signaling pathways in bovine immune regulation based on in vitro analysis results.

Strengths

• Data is derived from a controlled study analyzing PGE2 kinetics and Th1 responses in BLV-infected cattle.
• Includes both in vitro and in vivo analyses to support the proposed mechanism.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect a specific experimental context inherent to paperswithcode.

Provenance

Source

Hokkaido University

Collection Method

Experimental analysis of PGE2 concentrations and IFN-γ responses in BLV-infected pregnant cattle.