Evaluation of Candidate Reference Materials for Lassa Fever Serology Harmonization

West Africa is the endemic region for Lassa fever, a zoonotic disease. This dataset likely contains results from a multi-centre collaborative study involving 17 laboratories, evaluating a pooled plasma sample from survivors and monoclonal antibody cocktails as potential reference materials. The work was authored by Emma M. Bentley and last updated in April 2026.

Use Cases

• Harmonizing serological assay results across different laboratories based on the collaborative study design.
• Evaluating humoral immune responses to Lassa virus based on the described antibody titres and reference materials.
• Assessing the suitability of monoclonal antibody cocktails versus convalescent plasma as reference standards based on the study findings.
• Supporting the identification of surrogates of protection for Lassa fever vaccines based on the harmonized antibody data.

Strengths

• Data is derived from a collaborative study involving 17 laboratories, suggesting a multi-source validation.
• The study evaluated both a convalescent plasma pool and two monoclonal antibody cocktails, providing comparative material.
• License is CC-BY-4.0, permitting open sharing and adaptation.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (329.4 KB), indicating limited scope, likely focused on study results rather than raw clinical data.

Provenance

Source

figshare

Collection Method

Multi-centre collaborative study evaluating candidate reference materials.

Time Range

null

Freshness

Last updated 2026-04-30 17:21:21; freshness should be verified.

Geography

West Africa