Evaluation of β-lactamase production and efflux pump overexpression in clinical isolates o

A 2026 study by Indrani Gogoi investigates multidrug resistance mechanisms in clinical isolates of Klebsiella pneumoniae. It includes phenotypic and genotypic screening data, revealing co-occurrence of resistance genes in 46.25% of isolates and identifying 15 hub genes via computational network analysis. The dataset is available under a CC-BY-4.0 license.

Use Cases

• Identifying potential drug targets based on the 15 hub genes identified from the computational network.
• Analyzing the co-occurrence patterns of β-lactamase and efflux pump resistance genes mentioned in the description.
• Studying the prevalence of ESBL, AmpC, and metallo-β-lactamase phenotypes in clinical isolates.

Strengths

• Includes molecular detection results showing specific co-occurrence of resistance genes in 46.25% of isolates.
• Computational network analysis identified 15 hub genes and 97 functional partners, providing concrete targets for further study.
• Phenotypic screening data reveals specific resistance mechanisms like ESBL, AmpC, and metallo-β-lactamases.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 142.4 KB, indicating limited scope.

Provenance

Source

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Collection Method

Phenotypic and genotypic screening of clinical isolates followed by computational network analysis.

Freshness

Last updated 2026-05-26 08:47:05; freshness should be verified.