UCH-L1 Enzyme Levels in 260 Patients with Epilepsy and Healthy Volunteers

A study comparing Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) enzyme levels across 160 patients with epilepsy and 100 healthy volunteers. The dataset likely contains measurements for patients during epileptic seizures and non-seizure periods, with results indicating significantly higher UCH-L1 levels in epilepsy patients versus controls. The research was authored by İbrahim Halil Yasak and is available via the paperswithcode platform.

Use Cases

• Biomarker discovery for epilepsy diagnosis based on UCH-L1 enzyme levels.
• Comparative analysis of biomarker levels between seizure and non-seizure patient states.
• Evaluating the diagnostic sensitivity and specificity of UCH-L1 using ROC curve analysis parameters mentioned in the description.

Strengths

• Includes data from 260 total subjects (160 patients, 100 controls), providing a basis for statistical comparison.
• Reports specific median UCH-L1 levels (e.g., 8.30 ng/mL in epilepsy patients) and statistical significance (p<0.001).
• Defines a proposed diagnostic cut-off value (4.34 mg/mL) with associated sensitivity (93.75%) and specificity (66.00%).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

paperswithcode

Collection Method

Clinical study comparing UCH-L1 levels in patient groups and healthy volunteers.