PGAM5 Deletion in Macrophages During Early Atherosclerosis in Mouse Model

A 4-week study using CX3CR1creER/WT PGAM5flox/flox R26-tdTomato Ldlr-/- mice fed a tamoxifen-enriched high-fat diet. The dataset likely contains flow cytometry counts of immune cells in blood and measurements of plaque formation in aortic arch and heart sinus cross-sections. It was authored by Jesse Williams and published via Harvard Dataverse in May 2026.

Use Cases

• Analyze immune cell population changes based on flow cytometry data mentioned in the description
• Correlate PGAM5 gene deletion with plaque formation based on aortic and heart sinus measurements
• Model early atherosclerosis progression based on the 4-week high-fat diet intervention

Strengths

• Data is derived from a genetically modified mouse model with a specific 4-week dietary intervention.
• Analysis includes both systemic (blood flow cytometry) and localized (plaque) measurements.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Harvard Dataverse

Collection Method

Experimental data from a controlled mouse model study.

Freshness

Last updated 2026-05-11 14:29:37; freshness should be verified.