Exemplar QuPath Project for Striatal Segmentation in XDP and Normal Cases

A 1.3 MB exemplar QuPath project file demonstrates manual segmentation of striosomes and matrix in the post-mortem human striatum. The project, created by Adelie Tan, was utilized for a manuscript on striatal degeneration in X-linked Dystonia Parkinsonism and includes a subset of neurologically normal and XDP cohort data. It was last updated on May 19, 2026.

Use Cases

• Training segmentation models for striatal compartments based on DARPP-32 marker annotations
• Benchmarking automated segmentation algorithms against expert manual segmentations
• Studying regional and compartmental changes in neurodegenerative diseases like XDP
• Creating teaching materials for neuroanatomy and digital pathology workflows

Strengths

• Provides a 1.3 MB exemplar project with manual annotations for a specific neuropathological analysis
• Uses the DARPP-32 marker, a specific striosomal marker, for segmentation
• Includes data from both a neurologically normal cohort and an XDP cohort for comparison
• Released under a permissive CC-BY-4.0 license for reuse and adaptation

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The 1.3 MB size suggests it is a small exemplar or subset, not a full research dataset

Provenance

Source

figshare

Collection Method

Manual segmentation performed in QuPath software on post-mortem human tissue.

Time Range

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Freshness

Last updated 2026-05-19 22:10:03; freshness should be verified

Geography

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