Pseudomonas aeruginosa LasB Elastase Effects on Lung Epithelial Barrier Dysfunction

LasB elastase cleaves junctional protein E-cadherin and alters Claudin-4 localization in lung epithelial models. Roya Shafiei published this dataset on figshare in April 2026, detailing transcriptomic changes and cytokine reductions induced by LasB. The 3.3 MB ZIP file likely contains experimental data supporting antivirulence therapy research.

Use Cases

• Model dose-dependent epithelial barrier damage based on LasB concentration data
• Analyze transcriptomic gene expression changes, including DUSP2 and FGFBP1 upregulation
• Evaluate the efficacy of LasB inhibitors in restoring cytokine levels like GM-CSF and G-CSF
• Assess bacterial clearance and epithelial integrity preservation in live infection models

Strengths

• Includes data from bronchial and alveolar cell models, providing comparative insights
• Transcriptomic analysis reveals widespread gene expression changes
• Data supports findings on LasB inhibitors mitigating barrier disruption

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download

Provenance

Source

figshare

Collection Method

Experimental investigation using cell models and transcriptomic analysis

Freshness

Last updated 2026-04-10 09:43:29