Prenatal Organophosphate Ester Exposure and Autism-Related Outcomes in the ECHO Cohort

4159 mother-child pairs from 15 NIH ECHO Consortium cohorts were studied to investigate associations between prenatal organophosphate ester (OPE) exposure and child autism-related outcomes. Urinary concentrations of nine OPE biomarkers were measured during pregnancy and linked to Social Responsiveness Scale scores and clinical autism diagnoses for children born between 2006 and 2020. The research, authored by Jennifer L. Ames and shared on figshare, found specific OPEs like BBOEP and BCPP were associated with higher odds of autism diagnosis and related traits.

Use Cases

• Analyzing associations between specific urinary OPE biomarkers and autism-related trait scores based on the Social Responsiveness Scale.
• Investigating effect modification by child sex on the relationship between prenatal BBOEP exposure and neurodevelopmental outcomes.
• Modeling the odds of a clinical autism diagnosis based on categorical (high, moderate, nondetect) prenatal exposure levels.
• Examining cohort-level clustering effects in a multi-site environmental health study using generalized estimating equations.

Strengths

• Includes 4159 mother-child pairs, providing a substantial sample size for analysis.
• Data spans 15 cohorts from the NIH ECHO Consortium, offering multi-site representation.
• Children were born across a 14-year period (2006–2020), allowing for temporal analysis.
• Analysis includes nine specific OPE biomarkers and two distinct autism-related outcome measures.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for specific modeling tasks.
• Data may reflect temporal and cohort selection bias inherent to the participating ECHO studies.

Provenance

Source

NIH Environmental influences on Child Health Outcomes (ECHO) Consortium, 15 cohorts.

Collection Method

Urine samples collected mid- to late pregnancy, analyzed for nine OPE biomarkers. Child outcomes assessed via parent-reported Social Responsiveness Scale and clinical autism diagnosis.

Time Range

Pregnancy samples and child outcomes for births from 2006 to 2020.

Freshness

Last updated 2026-05-07 20:09:12; freshness should be verified.

Geography

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