Sucralose Exposure Effects on Mouse and Rat Testicular Cells and Sperm Viability

34.6 KB of experimental data from a study investigating the impact of the artificial sweetener sucralose on male reproductive health. The dataset, authored by Yi-Fen Chiang and shared on figshare in 2026, includes results from in vitro cell line experiments and a two-month in vivo rat exposure study. It likely contains measurements of cell survival rates, oxidative stress markers, autophagic flux disruption, and sperm viability.

Use Cases

• Analyze correlations between sucralose dosage and cell viability based on in vitro experiments described.
• Model the relationship between oxidative stress markers and impaired reproductive function based on the study's findings.
• Investigate the role of sweet taste receptor T1R3 signaling in testicular cell regulation based on protein expression data.
• Compare in vitro cell line results with in vivo reproductive outcomes from the two-month rat exposure study.

Strengths

• Data is derived from controlled laboratory experiments using established cell lines (TM3, TM4) and an animal model (SD rats).
• The study design includes both in vitro and in vivo components, with exposure durations up to two months.
• Dataset is shared under a CC-BY-NC-4.0 license, permitting non-commercial reuse with attribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset's 34.6 KB size suggests a limited scope, likely containing summary or processed results rather than raw high-throughput data.

Provenance

Source

figshare

Collection Method

Experimental data from laboratory studies on mouse Leydig and Sertoli cell lines and Sprague-Dawley rats.

Freshness

Last updated 2026-05-01 18:09:28; freshness should be verified.