Extremely High Alkaline Phosphatase in Pregnancy: Case Series and Literature Review

A retrospective case series from a single university-affiliated medical center between 2010 and 2018, combined with a literature review. It includes 21 parturients with alkaline phosphatase levels above 1000 U/L, reporting perinatal outcomes. The study was authored by Renana Wilkof‐Segev of the Hillel Yaffe Medical Center.

Use Cases

• Investigating the association between extremely elevated alkaline phosphatase levels and adverse perinatal outcomes.
• Analyzing the prevalence of conditions like gestational diabetes and hypertensive disorders in patients with high ALKP.
• Reviewing placental histopathology findings linked to elevated enzyme levels.
• Studying the gestational age at delivery and preterm birth rates in this patient cohort.

Strengths

• Includes 21 cases, which the authors describe as the largest case series on this topic.
• Reports specific median ALKP levels (1880 U/L) and ranges (1052-4488 U/L).
• Provides detailed clinical data, including isoenzyme analysis results and placental histopathology findings.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• Data is from a single medical center and may reflect geographic or institutional bias.
• Last update date is unknown; freshness unverified.

Provenance

Source

Hillel Yaffe Medical Center

Collection Method

Retrospective case series combined with a PubMed literature review.

Time Range

2010-2018

Geography

Data from a single university-affiliated medical center; geographic scope unspecified.