FASN-AMPK-MTOR Pathway Data for Early Age-Related Macular Degeneration

Jinyu Cai published transcriptomic and experimental data on figshare in 2026, investigating the role of FASN in autophagy and lipid metabolism in early age-related macular degeneration (AMD). The dataset includes results from human macular tissue analysis and in vitro RPE cell experiments, with files totaling 11.1 MB in DOCX and XLSX formats. The data is licensed under CC-BY-4.0.

Use Cases

• Validate the identified FASN hub gene expression in early AMD based on the described human transcriptomic analysis.
• Model the crosstalk between autophagy and lipid metabolism based on the described AMPK-MTOR pathway interactions.
• Analyze lysosomal function and lipid clearance in RPE cells based on the described in vitro experiments with inhibitors and activators.
• Investigate therapeutic targets for early AMD based on the described FASN-AMPK-MTOR axis.

Strengths

• Includes data from both human tissue samples and controlled mouse and cell line experiments, as described.
• Dataset is openly available under a permissive CC-BY-4.0 license.
• Files are provided in common, accessible formats (DOCX, XLSX).

Limitations

• Row count and specific column definitions are unknown, which limits suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect experimental bias inherent to the specific study design described.

Provenance

Source

figshare, author Jinyu Cai.

Collection Method

Likely contains experimental results from transcriptomic analysis of human tissues, studies on apoe−/− mice fed a high-fat diet, and in vitro RPE cell treatments.

Freshness

Last updated 2026-05-19 05:20:55; freshness should be verified.