FEA-Guided Co-Design of Bubble Microneedles for Transdermal and Sublingual Delivery

Finite element analysis simulations predicted stress localization at engineered cavities, reducing transverse separation forces to 5.23 N and 4.17 N for two drug models. The dataset includes experimental validation showing axial failure loads of 0.13 N and 0.28 N, exceeding penetration thresholds for skin and mucosa. This work by Changzhao Jiang, published on figshare in 2026, establishes a semi-quantitative screening approach for separable microneedle systems.

Use Cases

• Optimizing microneedle geometry for controlled tip separation based on FEA-predicted stress localization.
• Designing rapid drug delivery systems based on payload liberation exceeding 80% within 10 minutes.
• Evaluating insertion robustness for skin and mucosal penetration based on measured axial failure loads.
• Comparing delivery efficiency of microneedles versus topical gels based on ex vivo Franz diffusion test results.

Strengths

• Includes specific, validated force measurements: transverse separation forces of 5.23 N and 4.17 N, with axial failure loads of 0.13 N and 0.28 N.
• Demonstrates practical efficacy: microneedles achieved approximately sevenfold greater cumulative drug permeation than an equivalent-dose topical gel.
• Provides in vivo validation: accelerated hair regrowth in mice and rapid glucose lowering in diabetic rats comparable to subcutaneous injection.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (199.7 KB), indicating limited scope, likely containing summary results rather than raw simulation or experimental data.

Provenance

Source

figshare

Collection Method

Likely contains results from finite element analysis simulations and experimental validation using minoxidil sulfate-loaded and insulin-loaded bubble microneedles.

Freshness

Last updated 2026-05-12 16:52:21; freshness should be verified.