Ferroptosis inhibition and mitochondrial rescue: a novel mechanism of emodin in rheumatoid

Linlan Zhou's dataset investigates the therapeutic mechanism of emodin in rheumatoid arthritis using collagen-induced arthritis mice and lipopolysaccharide-stimulated RAW264.7 macrophages. The data includes analyses of joint pathology, inflammation, oxidative stress, ferroptosis, and mitochondrial function from techniques like histology, micro-CT, western blotting, and proteomics. It supports the conclusion that emodin ameliorates arthritis by suppressing ferroptosis via the GPX4/ACSL4 axis.

Use Cases

• Validating ferroptosis-related protein expression (GPX4/ACSL4) based on western blot and immunohistochemistry data
• Correlating joint bone destruction with inflammatory markers based on micro-CT and cytokine analysis
• Modeling drug-target interactions for emodin based on molecular docking and dynamics simulations
• Identifying potential therapeutic pathways in RA based on proteomics and network pharmacology results
• Assessing mitochondrial function and oxidative stress in an arthritis model based on microscopy and assay data

Strengths

• Dataset is openly available under a CC-BY-4.0 license, facilitating reuse and redistribution
• Research employs a multi-method validation approach, including in vivo models, cellular assays, and computational techniques
• Cross-platform presence on figshare indicates established sharing and potential for visibility

Limitations

• Column names and a precise row count are not provided, limiting immediate understanding of data structure
• The dataset's primary file formats (PDF, DOCX) suggest it may contain processed results and reports rather than raw, machine-readable data tables
• Metadata lacks information on the author's organization and specific data collection protocols

Provenance

Source

Linlan Zhou

Collection Method

Data generated from experimental studies on collagen-induced arthritis mice and RAW264.7 macrophages, analyzed via histology, micro-CT, western blot, immunohistochemistry, microscopy, proteomics, and computational modeling.

Time Range

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Freshness

Last updated on 2026-03 23

Geography

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