FGFR1 Neddylation: Breast Cancer Proteomics and Signaling Data

A dataset from a 2026 study investigating the role of neddylation in stabilizing Fibroblast growth factor receptor 1 (FGFR1) in breast cancer. It includes results from DIA quantitative proteomics screening, protein stability assays, and downstream signaling analysis following neddylation inhibition. The data was authored by Junfang Qin and shared under a CC-BY-4.0 license.

Use Cases

• Identify differentially expressed proteins associated with neddylation based on DIA proteomics screening results.
• Analyze FGFR1 protein stability and downstream signaling pathways following pharmacological or genetic neddylation inhibition.
• Investigate correlations between neddylation pathway activity and malignant progression in breast cancer models.

Strengths

• Includes data from both clinical databases and experimental models, providing translational context.
• Contains results from DIA quantitative proteomics, a high-resolution mass spectrometry technique.
• Data is shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, authored by Junfang Qin.

Collection Method

Employed clinical databases, experimental models, DIA quantitative proteomics, Western blotting, and qPCR analysis.

Freshness

Last updated 2026-04-25 01:53:03; freshness should be verified.