Fluid Biomarker Review for Glaucoma Surgery Outcomes

353 biomarkers have been studied for their association with failed glaucoma surgery, including MCP-1, TGF-β, and VEGF. This systematic review synthesizes findings from 20 articles published up to December 2025, authored by Roderick E. Gachette. It analyzes biomarkers in aqueous humor, tear fluid, and Tenon tissue related to post-surgical fibrosis.

Use Cases

• Identify pro-inflammatory biomarkers like IL-6 and IL-8 in aqueous humor linked to surgical failure.
• Analyze the relationship between anti-inflammatory biomarker levels and successful surgery outcomes across different fluid types.
• Compare biomarker profiles (e.g., MMP-3, SPARC) between aqueous humor, tear fluid, and Tenon tissue for fibrosis research.
• Validate potential predictive panels using the 353 studied biomarkers for machine learning feature selection.

Strengths

• Aggregates findings from 20 distinct research articles.
• Documents 353 specific biomarkers studied in relation to glaucoma surgery outcomes.
• Explicitly lists significant biomarkers like TGF-β, VEGF, and multiple interleukins.

Limitations

• The underlying dataset is a 476.8 KB PDF, containing only review text with no raw, structured data for analysis.
• High variability and inconsistency in biomarker findings across the 20 source studies is noted.
• Sample sizes and original patient data from the reviewed studies are not provided.

Provenance

Source

Systematic search of Embase and MEDLINE databases, supplemented by snowball method.

Collection Method

Systematic literature review.

Time Range

Articles published until December 5, 2025.

Freshness

Literature search includes articles published until December 5, 2025; the review itself was last updated in April 2026.