Mouse Calvaria Bone Growth Data from 15-Day STS-131 Spaceflight Mission

Seven adult female C57BL/6 mice were exposed to 15 days of microgravity on the STS-131 mission, with eight littermates as ground controls. Their calvariae were imaged via micro-computed tomography, and three parameters—bone volume (BV), average cortical thickness (Ct.Th), and tissue mineral density (TMD)—were measured. The dataset contains grouped mCT data derived from this literature, showing a statistically significant increase in BV for the spaceflight group.

Use Cases

• Analyze the effect of microgravity on non-weight-bearing bones based on bone volume (BV), cortical thickness (Ct.Th), and tissue mineral density (TMD) measurements.
• Model bone adaptation responses to skeletal unloading and fluid shifts based on the comparison between spaceflight and ground control groups.
• Validate hypotheses about head-ward fluid redistribution in microgravity using quantitative bone morphometry data.

Strengths

• Data originates from a controlled spaceflight experiment on the STS-131 mission.
• Includes specific statistical results: mean BV for the spaceflight group was 1.904 ± 0.842 mm³ versus 1.758 ± 0.122 mm³ for controls (p < 0.05).
• Compares two distinct cohorts: a spaceflight group of 7 mice and a ground control group of 8 littermates.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset contains only grouped mCT data, not individual raw scans or measurements.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Derived from literature; micro-computed tomography scans of murine calvariae post-mission.

Time Range

Data collection corresponds to the STS-131 mission.

Freshness

Last updated 2026-03-13 19:54:47.361629; freshness should be verified.

Geography

null