Figure S5D: Antibody Neutralization Potency Against Andes Virus

508.2 KB of data comparing the neutralization potency of two antibody variants, ADI-65534-IgG1 and ADI-65534-IgG3, against Andes virus entry. The dataset includes normalized infectivity measurements from 8 wells per antibody dilution across three independent experiments, with statistical analysis (p=0.0008). Nicole Johnson published this data on figshare under a CC-BY-4.0 license, last updated on 2026-04 14.

Use Cases

• Compare antibody neutralization efficacy based on IgG subclass differences described in the experiment.
• Analyze dose-response relationships for antibody blockade of viral entry using the provided IC50 values.
• Validate statistical significance of experimental results using the paired t-test with Welch's correction mentioned.
• Model virus neutralization curves based on normalized infectivity data from Vero cell assays.

Strengths

• Includes statistical significance results (p=0.0008) from a paired t-test with Welch's correction.
• Data is derived from three independent experiments with 8 replicates per condition, suggesting methodological rigor.
• Available in common analysis formats (PRISM, XLSX) totaling 508.2 KB.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset's scope is limited to a single comparative figure (Figure S5D).

Provenance

Source

figshare, author Nicole Johnson.

Collection Method

Laboratory assay measuring antibody blockade of rVSV-ANDV-Gn/Gc entry in Vero cells.

Time Range

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Freshness

Last updated 2026-04-14 18:51:25; freshness should be verified.

Geography

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