Figure S6D: Mouse Immune Response to ANDV RNA Vaccine Constructs

Figure S6D contains ELISpot assay data measuring interferon-gamma responses in mouse splenocytes. The data, published by Luqiang Guo on figshare in April 2026, shows spot counts per million cells for mice immunized with different doses of ANDV-GPC repRNA/LION constructs and stimulated with peptide pools. Statistical analysis was performed using one-way ANOVA with Tukey's test, and results are presented as means with standard deviation.

Use Cases

• Compare immune response magnitude based on vaccine dose (1 μg vs 10 μg) mentioned in the description
• Analyze statistical significance of differences in ELISpot responses using the ANOVA method described
• Validate vaccine immunogenicity based on interferon-gamma production data from mouse splenocytes

Strengths

• Data includes statistical analysis results (one-way ANOVA with Tukey's test)
• Spot counts are normalized per 10⁶ splenocytes with background subtraction
• Available under a permissive CC-BY-4.0 license

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Dataset is very small at 11.2 KB, indicating limited scope

Provenance

Source

Luqiang Guo via figshare

Collection Method

Experimental data from ELISpot assays on immunized mouse splenocytes

Time Range

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Freshness

Last updated 2026-04-14 18:51:09

Geography

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